I purchased NR1222 for my 3 1/2 year old daughter who has JRA in her right knee, ankle and wrist. She presently is taking too many pills. At first I was very skeptical but my daughter now requests NR1222 whenever she’s having her stiff mornings and I’m gratified that at least there is something out there I can rub on her joints that helps relieve her pain. Thanks Natural Relief!